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June 14, 2010There are a number of conditions resulting from improperly developed adrenal glands or adrenal glands whose function have been impaired through the development of tumors. Like the famous disease named after Doctor Thomas Addison, Addison’s Disease results from the lack of specific hormones produced by the glands. One such affliction is called Adrenocortical Insufficiency and can be treated with a combination of drugs including Florinef.
Unlike the disease named for the first physician to describe its symptoms in detail, Adrenocortical insufficiency is named for its causality. There are two types of this disease: primary, which directly involves the adrenal glands, and secondary, a condition in which the pituitary gland produces inadequate hormones. These can be autoimmune diseases or the result of the development of cancer.
Symptoms of this disease are difficult to recognize without considerable experience as they appear insidiously and many of them are present with a variety of other afflictions. Commonly the patient experiences fatigue and muscle weakness. This may be presumed to be from the constant lack of sodium in the body which, in combination with potassium, is required for muscle contraction.
Patients suffering this malady frequently have low levels of blood sugar, or hypoglycemia as seen in diabetes. This feature of the illness is of particular concern as it affects the amount of sugar provided to the brain. Levels of blood sugar reaching too low can result in loss of vision, seizures, brain damage and even death.
Affected people also characteristically suffer from a classic symptom of Addison disease: the abrupt loss of blood pressure upon standing known as Orthostatic Hypotension. In addition, a general feeling of malaise accompanied by weakness and fatigue are definitive. A patient showing with these symptoms may be difficult to accurately give a diagnosis to, due to the similarity in the cluster of symptoms and a test for levels of serum adrenocorticotropic hormone may be necessary.
Other important signs include a hyper-pigmentation of the skin, especially at areas where the body bends or folds such as in the hands. Because this condition and others with adrenal insufficiency result in an overall greater loss of sodium though voiding, patients often indicate a strong desire for salty foods. It is important to correctly diagnose and treat the disease before it reaches the point of an Addisonian crisis.
This condition, left untreated can result in cardiac arrest and death. At puberty, the male child has small testicles, an enlarged phallus and experiences frequent erections.
Treatment is needed to replace the cortisol and aldosterone which is missing due to the adrenal gland’s inability to produce it. A common method is to administer both Florinef and Hydrocortizone.
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